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Currently, excessive NNMT upregulation is implicated in several scenarios, including obesity, metabolic diseases, muscle cell degeneration, and even some types of cancer [2, 4]

Tumour Biol 34:39233931

Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet

By elevating NAD+ levels and optimizing energy metabolism, it achieves favorable effects in body weight control and blood glucose regulation